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SV119

CAT: 0013-GTR19272893-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272893-02Size:50 mg
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Description
SV119 is a selective σ-2 receptor (σ2 receptor) ligand with a Ki of approximately 5-10 nM. It induces apoptosis in various human cancer cell lines by activating caspase-3 and promoting mitochondrial depolarization. SV119 can enhance the effects of chemotherapeutic agents such as Paclitaxel, improving their cytotoxicity against tumor cells. In mouse xenograft models, SV119 significantly inhibits tumor growth both alone and in combination. SV119 is applicable for research on cancers such as breast, prostate, and pancreatic cancer.
CAS Number
913815-82-4
Smiles
C (CCCCCN) N1[C@@]2 (C[C@@H] (OC (NC3=C (OC) C=CC (C) =C3) =O) C[C@]1 (CCC2) [H]) [H]
Molecular Formula
C23H37N3O3
Molecular Weight
403.57
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(1R,3r,5S)-9-(6-Aminohexyl)-9-azabicyclo[3.3.1]nonan-3-yl (2-methoxy-5-methylphenyl)carbamate
CAS Number913815-82-4
PubChem CID24772870
IUPAC Name[(1R,5S)-9-(6-aminohexyl)-9-azabicyclo[3.3.1]nonan-3-yl] N-(2-methoxy-5-methylphenyl)carbamate
Molecular FormulaC23H37N3O3
Molecular Weight403.6
XLogP3.9
Topological Polar Surface Area76.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Heavy Atom Count29
Formal Charge0
Complexity490
SMILES
CC1=CC(=C(C=C1)OC)NC(=O)OC2C[C@H]3CCC[C@@H](C2)N3CCCCCCN
InChI
InChI=1S/C23H37N3O3/c1-17-10-11-22(28-2)21(14-17)25-23(27)29-20-15-18-8-7-9-19(16-20)26(18)13-6-4-3-5-12-24/h10-11,14,18-20H,3-9,12-13,15-16,24H2,1-2H3,(H,25,27)/t18-,19+,20?
InChIKey
LKFLCBUCBHTSTF-YOFSQIOKSA-N
Chemical Structure
2D Structure
2D structure of (1R,3r,5S)-9-(6-Aminohexyl)-9-azabicyclo[3.3.1]nonan-3-yl (2-methoxy-5-methylphenyl)carbamate
CAS: 913815-82-4
CID: 24772870
Formula: C23H37N3O3
MW: 403.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight403.6
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass403.28349205
Monoisotopic Mass403.28349205
Topological Polar Surface Area76.8 Ų
Heavy Atom Count29
Formal Charge0
Complexity490
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-177345SV119
HY-177345ASV119 (hydrochloride)

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