Products for Research Use Only
RegisterLogin

Desmethylastemizole

CAT: 0013-GTR19272889-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19272889-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Desmethylastemizole (O-Demethylastemizole) is a metabolite of Astemizole and acts as a β-hematin (βH) inhibitor. It exhibits antimalarial activity against Plasmodium falciparum strains Pf3D7, PfDd2, and PfItG with IC50 values of 0.12 μM, 0.11 μM, and 0.06 μM, respectively. Additionally, Desmethylastemizole functions as a histamine H1 receptor antagonist and significantly blocks the hERG K+ channel while inhibiting the activity of the histone-lysine N-methyltransferase EZH2. It is utilized in studies of long QT syndrome and malaria.
CAS Number
73736-50-2
Smiles
FC1=CC=C (C=C1) CN2C (=NC=3C=CC=CC32) NC4CCN (CCC5=CC=C (O) C=C5) CC4
Molecular Formula
C27H29FN4O
Molecular Weight
444.55
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
HY-W516880Desmethylastemizole
AR-A02690-01O-Desmethylastemizole-d4

Popular Products