SN38- (PEG) 2-Pom-α

CAT: 0013-GTR19277106-01Size: 50 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19277106-01Size:50 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SN38- (PEG) 2-Pom-α is a selective PROTACRPL15 degrader. It induces ubiquitin-mediated degradation of RPL15 without affecting TOP1. Additionally, SN38- (PEG) 2-Pom-α can prompt cancer cells to secrete damage-associated molecular patterns (DAMPs), activating the cGAS-STING pathway in dendritic cells. In a human CRBN-expressing mouse melanoma model, SN38- (PEG) 2-Pom-α demonstrates synergistic tumor growth inhibition when used in combination with anti-PD-1 antibodies. This compound is valuable for melanoma research.

Storage Conditions

-20°C

Notes

For research use only.

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SN38- (PEG) 2-Pom-α

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