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PTPN2/1-IN-4

CAT: 0013-GTR19273649-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273649-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTPN2/1-IN-4 (Compound WS35) is an orally active dual inhibitor of PTPN1 and PTPN2, with IC50 values of 12.8 nM and 5.8 nM, respectively. It modulates the IFNγ-JAK-STAT signaling pathway and significantly enhances CD8+ T cell tumor infiltration. PTPN2/1-IN-4 demonstrates potent anticancer activity, effectively inhibiting tumor growth in the B16-OVA syngeneic mouse model both as a monotherapy and in combination with anti-PD-1 antibody treatment.
CAS Number
3093350-55-8
Smiles
O=C1NS (=O) (=O) N (C2=C (F) C=C (C=C2O) C=3C=NC (NCCC (C) C) =C (C3) C) C1
Molecular Formula
C19H23FN4O4S
Molecular Weight
422.48
Storage Conditions
-20°C
Notes
For research use only.

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