CD30 Recombinant Rabbit Monoclonal Antibody [PSH04-10]

CD30 Recombinant Rabbit Monoclonal Antibody [PSH04-10]

• Description: CD30, also known as TNFRSF8 (TNF receptor superfamily member 8), is a cell membrane protein of the tumor necrosis factor receptor family and a tumor marker. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. CD30 and CD15 are also expressed on Reed-Sternberg cells typical for Hodgkin's lymphoma.
• Product Name Alternative: CD 30 antibody CD30 antibody CD30 antigen antibody CD30L receptor antibody Cytokine receptor CD30 antibody D1S166E antibody KI 1 antibody KI 1 antigen antibody Ki-1 antigen antibody KI1 antibody Lymphocyte activation antigen CD30 antibody TNFRSF 8 antibody Tnfrsf8 antibody TNR8_HUMAN antibody Tumor necrosis factor receptor superfamily member 8 antibody
• Abbreviation: TNFRSF8, CD30, D1S166E
• CAS Number: 9000-83-3
• Swiss Prot: P28908 Human
• Cellular Locus: Cell membrane; Cytoplasm.
• Host: Rabbit
• Species Reactivity: Human
• Immunogen: Recombinant protein within human CD30 aa 1-385 / 595.
• Isotype: IgG
• Clone: PSH04-10
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: HDLM-2 cell lysate, HUT 102 cell lysate, human anaplastic large cell lymphoma tissue, human embryonal carcinoma tissue, human tonsil tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000 ;IHC-P: 1:500-1:1,500
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 64 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes