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Piperonylic acid

CAT: 0804-HY-41404-01Size: 10 gDry Ice: NoHazardous: No
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CAT#:0804-HY-41404-01Size:10 g
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Description
Piperonylic acid is a natural molecule bearing a methylenedioxy function that closely mimics the structure of trans-cinnamic acid. Piperonylic Acid is a selective, mechanism-based inactivator of the trans-cinnamate 4-Hydroxylase. Piperonylic acid has anticancer, antioxidant and antibacterial activities[1][2][3][4].
CAS Number
94-53-1
Product Name Alternative
2H-1,3-benzodioxole-5-carboxylic acid
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450; EGFR; IGF-1R; Interleukin Related
Type
Natural Products
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Others
Assay Protocol
https://www.medchemexpress.com/piperonylic-acid.html
Purity
99.97
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(OCO2)C2=C1)O
Molecular Formula
C8H6O4
Molecular Weight
166.13
Precautions
H302, H315, H319, H335
References & Citations
[1]Schalk M, et al, Werck-Reichhart D. Piperonylic acid, a selective, mechanism-based inactivator of the trans-cinnamate 4-hydroxylase: A new tool to control the flux of metabolites in the phenylpropanoid pathway. Plant Physiol. 1998;118 (1) :209‐218.|[2]Lee D, et al. Piperonylic acid stimulates keratinocyte growth and survival by activating epidermal growth factor receptor (EGFR) . Sci Rep. 2018 Jan 9;8 (1) :162. |[3]Zarai, Zied, et al. "Antioxidant and antimicrobial activities of various solvent extracts, piperine and piperic acid from Piper nigrum." Lwt-Food science and technology 50.2 (2013) : 634-641. |[4]Moreira KG, et al. Accelerative action of topical piperonylic acid on mice full thickness wound by modulating inflammation and collagen deposition. PLoS One. 2021 Oct 26;16 (10) :e0259134.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; IL-10; IL-6

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