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HBI-2375

CAT: 0013-GTR19264667-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264667-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HBI-2375 (HYBI-084) is a selective inhibitor that penetrates the blood-brain barrier and is orally active, targeting the MLL1-WDR5 interaction. It inhibits WDR5 with an IC50 of 4.48 nM and demonstrates antiproliferative activity in MV4;11 leukemia cells with an IC50 of 3.17 μM. Furthermore, HBI-2375 disrupts histone methyltransferase activity in cancer cells and is useful for researching leukemia, glioma, and glioblastoma.
CAS Number
2982574-79-6
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N (C (=O) C1=C (Cl) C (C) =C (F) C (N) =C1) C2=C (C=C (F) C (=C2) N3C=C (C (=O) N4CCN (C) CC4) N=N3) N5C[C@@H] (C) N (C) [C@@H] (C) C5
Molecular Formula
C29H36ClF2N9O2
Molecular Weight
616.11
Storage Conditions
-20°C
Notes
For research use only.

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