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GNE-5152

CAT: 0013-GTR19265401-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19265401-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GNE-5152 is a straight-chain SARM1 base exchange (BE) inhibitor. Under mild activation conditions, GNE-5152 persistently activates SARM1 at sub-inhibitory concentrations, which synergistically enhances NAD consumption, leading to axonal degeneration and neurodegeneration, and releases neurofilament light chain (NfL) in cortical neurons. GNE-5152 is applicable in neurodegenerative disease research.
CAS Number
3080315-83-6
Field of Research
Immunology & Inflammation
Smiles
O=C1N (C=2C=NC (=CC2) C=3C=CN=CC3) CCC (C4=CC=C (F) C (F) =C4) C1
Molecular Formula
C21H17F2N3O
Molecular Weight
365.38
Storage Conditions
-20°C
Notes
For research use only.

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