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JAK1-IN-18

CAT: 0013-GTR19264398-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264398-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK1-IN-18 (Example 2) is a selective JAK1 inhibitor with an IC50 value of 0.15 nM, demonstrating significantly greater inhibitory potency for JAK1 compared to JAK2 and JAK3. It significantly reduces inflammation in ulcerative colitis (UC) mouse models induced by DSS and Crohn's disease (CD) rat models induced by DNBS. JAK1-IN-18 is applicable for research into autoimmune diseases (such as inflammatory bowel disease), viral infections (such as hepatitis B virus infection), and cancers (such as hematologic malignancies) .
CAS Number
2459377-98-9
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N (C1=C2C (=NC=C1C (N) =O) NC=C2) N3C[C@@H] (C (NCC (F) F) =O) CCC3
Molecular Formula
C16H20F2N6O2
Molecular Weight
366.37
Storage Conditions
-20°C
Notes
For research use only.

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