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JAK3-IN-18

CAT: 0013-GTR19264149-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264149-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK3-IN-18 is a selective and orally active dual inhibitor targeting JAK3 and TEC, with IC50 values of 0.5391 nM and 12.40 nM, respectively. It demonstrates remarkable selectivity for AK1, AK2, and TYK2, with selectivity ratios exceeding 10,000-fold. JAK3-IN-18 exhibits exceptional therapeutic efficacy in a mouse model of experimental autoimmune encephalomyelitis and is applicable for multiple sclerosis research.
CAS Number
2914873-59-7
Field of Research
Cardiovascular Research, Epigenetics & Chromatin, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N ([C@@H]1C=2C (CN (C (C=C) =O) C1) =CC (F) =CC2) C3=C4C (NC=C4) =NC=N3
Molecular Formula
C18H16FN5O
Molecular Weight
337.35
Storage Conditions
-20°C
Notes
For research use only.

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