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EP2 receptor antagonist-3

CAT: 0013-GTR19264278-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264278-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EP2 receptor antagonist-3 is a selective antagonist of the EP2 receptor, with an IC50 of 8 nM determined in the hEP2 SPA assay and an IC50 of 50 nM in the hEP2 cAMP assay. It enhances macrophage-mediated clearance of Amyloid-β plaques. In CD-1 mice, it shows moderate clearance and good exposure, and exhibits good central nervous system (CNS) exposure in both mice and rats. EP2 receptor antagonist-3 is applicable for research in Alzheimer's disease.
CAS Number
1799626-16-6
Field of Research
Immunology & Inflammation, Neuroscience, Pharmacology & Drug Discovery
Smiles
O=C1C=C (C=CN1) CN2CC3=CC (=CC (Cl) =C3OCC2) N4C=CC=5C=C (F) C=CC54
Molecular Formula
C23H19ClFN3O2
Molecular Weight
423.87
Storage Conditions
-20°C
Notes
For research use only.

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