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SF-9-2

CAT: 0013-GTR19264277-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264277-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SF-9-2 is a PD-L1/PD-1 binding inhibitor with an IC50 of 24.9 nM. It suppresses epithelial-mesenchymal transition, migration, invasion, and proliferation of SK-N-SH cells, while also inducing apoptosis and causing cell cycle arrest. SF-9-2 blocks PD-L1-induced growth of SK-N-SH cells via the MAPK signaling pathway. It restores GSK-3β activity and enhances PD-L1 degradation through the ubiquitin-proteasome pathway. In the SK-N-SH NOG mouse model, SF-9-2 inhibits tumor growth without notable toxicity. Additionally, SF-9-2 acts as an immune checkpoint inhibitor, blocking PD-L1 to restore T cell function and is applicable to neuroblastoma research.
CAS Number
3053768-78-5
Field of Research
Cell Biology, Immunology & Inflammation, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Smiles
N#CC1=CN=CC (=C1) COC2=CC (OCC3=CC=CC (C=4C=CC=CC4F) =C3CF) =CC=C2CNCCO
Molecular Formula
C30H27F2N3O3
Molecular Weight
515.55
Storage Conditions
-20°C
Notes
For research use only.

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