Products for Research Use Only

Ro 31-8220 formic

CAT: 0013-GTR19263723-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263723-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro 31-8220 formic is a potent inhibitor of protein kinase C (PKC), specifically targeting PKCα, PKCβI, PKCβII, PKCγ, PKCε, and rat brain PKC, with IC50 values of 5, 24, 14, 27, 24, and 23 nM, respectively. It also inhibits MAPKAP-K1b, MSK1, S6K1, and GSK3β, with IC50 values of 3, 8, 15, and 38 nM. Additionally, Ro 31-8220 formic suppresses the expression of MKP-1, induces c-Jun expression, and activates JNK, exhibiting these effects through mechanisms independent of PKC.
Field of Research
Epigenetics & Chromatin, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.