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TR antagonist 2

CAT: 0013-GTR19263650-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263650-01Size:10 mg
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Description
TR antagonist 2 (Compound 10a) is a competitive inhibitor of thyroid hormone receptors (TRα/β) with an IC50 of 47 nM. It works by competitively binding to the ligand-binding domain of the receptor with triiodothyronine (T3), thereby blocking the formation of the receptor-coactivator complex, inhibiting target gene transcription, and reducing thyroid hormone-mediated metabolic effects. TR antagonist 2 holds potential for research into hyperthyroidism (such as Graves' disease) and thyrotoxicosis.
CAS Number
1073179-55-1
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Smiles
O=C (NNC (=O) CC1=CCN (C2=CC=C (C=C2) N (=O) =O) CC1) NC3=CC=CC (=C3) C (F) (F) F
Molecular Formula
C21H20F3N5O4
Molecular Weight
463.41
Storage Conditions
-20°C
Notes
For research use only.

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