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KIN-8741

CAT: 0013-GTR19263581-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263581-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KIN-8741 is a highly selective and orally active Type IIb c-Met inhibitor. It exhibits broad-spectrum activity against c-Met kinase mutations. KIN-8741 demonstrates antitumor activity in non-small cell lung cancer models with MET gene amplification and exon 14 deletion. It is applicable in research on c-Met-driven cancers, particularly advanced tumors harboring MET exon 14 skipping mutations and acquired resistance mutations.
CAS Number
2941104-53-4
Field of Research
Epigenetics & Chromatin, Signal Transduction
Smiles
O (C=1C2=C (C=C (OC) C (O[C@H] (CO) C) =C2) N=CC1) C3=C (F) C=C (NC (=O) C=4C (OC) =CC=NC4) C=C3F
Molecular Formula
C26H23F2N3O6
Molecular Weight
511.47
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 168842984
CAS Number2941104-53-4
PubChem CID168842984
IUPAC NameN-[3,5-difluoro-4-[6-[(2S)-1-hydroxypropan-2-yl]oxy-7-methoxyquinolin-4-yl]oxyphenyl]-4-methoxypyridine-3-carboxamide
Molecular FormulaC26H23F2N3O6
Molecular Weight511.5
XLogP3.3
Topological Polar Surface Area112
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Heavy Atom Count37
Formal Charge0
Complexity726
SMILES
C[C@@H](CO)OC1=CC2=C(C=CN=C2C=C1OC)OC3=C(C=C(C=C3F)NC(=O)C4=C(C=CN=C4)OC)F
InChI
InChI=1S/C26H23F2N3O6/c1-14(13-32)36-24-10-16-20(11-23(24)35-3)30-7-5-22(16)37-25-18(27)8-15(9-19(25)28)31-26(33)17-12-29-6-4-21(17)34-2/h4-12,14,32H,13H2,1-3H3,(H,31,33)/t14-/m0/s1
InChIKey
GCIKJNJUNJFZPR-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of CID 168842984
CAS: 2941104-53-4
CID: 168842984
Formula: C26H23F2N3O6
MW: 511.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight511.5
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass511.15549179
Monoisotopic Mass511.15549179
Topological Polar Surface Area112 Ų
Heavy Atom Count37
Formal Charge0
Complexity726
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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