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SB-T-101141

CAT: 0013-GTR19263516-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263516-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SB-T-101141 is a novel taxane drug effective in inducing atypical ferroptosis, thereby overcoming resistance of breast cancer to Paclitaxel. It promotes the generation of iron ions, ferrous ions, and reactive oxygen species (ROS) . SB-T-101141 stably binds to KHSRP, inhibiting the expression of the iron-dependent CISD1 related to iron homeostasis. It synergistically enhances the activation of the iron-dependent JNK and PERK pathways through KHSRP. SB-T-101141 inhibits breast tumor growth in MCF-7 (PR) /MDA-MB-231 (PR) or KHSRP knockout MCF-7 xenograft mouse models.
CAS Number
186348-05-0
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
O (C (=O) C1=CC=CC=C1) [C@@H]2[C@]34[C@] ([C@H] (OC ([C@@H] ([C@@H] (NC (OC (C) (C) C) =O) C=C (C) C) O) =O) C (C) =C (C3 (C) C) [C@@H] (OC (C) =O) C (=O) [C@@]5 (C) [C@]2 ([C@@]6 (OC (C) =O) [C@] (OC6) (C[C@@H]5O) [H]) [H]) (OC (=O) O4) [H]
Molecular Formula
C44H55NO17
Molecular Weight
869.90
Storage Conditions
-20°C
Notes
For research use only.

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