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ZAK-IN-1

CAT: 0013-GTR19263271-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263271-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZAK-IN-1 is an orally active and selective inhibitor of the leucine zipper and sterile-alpha motif kinase ZAK, with an IC50 of 4 nM and a KD of 8 nM. It demonstrates exceptional selectivity against 403 types of wild-type kinases. ZAK-IN-1 effectively blocks the p38/GATA-4 and JNK/c-Jun signaling pathways, significantly suppressing cardiac hypertrophy. This compound is applicable in the study of hypertrophic cardiomyopathy (HCM) .
CAS Number
2362525-64-0
Field of Research
Signal Transduction
Smiles
O=S (=O) (NC1=CC=C (F) C (=C1F) N2N=NC (=C2) C=3C=NC=4NN=C (OC) C4C3) C5=CC=CC (=C5) C=6C=CC=CC6
Molecular Formula
C27H19F2N7O3S
Molecular Weight
559.55
Storage Conditions
-20°C
Notes
For research use only.

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