Products for Research Use Only

PI3K/mTOR-IN-17

CAT: 0013-GTR19263253-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263253-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3K/mTOR-IN-17 is a dual inhibitor that targets both PI3K and mTOR, with IC50 values of 1.21 μM and 0.21 μM, respectively. It induces apoptosis mediated by caspases and arrests cell growth in the G1 phase. The compound elevates the levels of caspases-3, 7, 8, and 9, enhances p53 expression, and increases the Bax/Bcl-2 ratio. By inhibiting the PI3K/mTOR signaling pathway, PI3K/mTOR-IN-17 is applicable in cancer research, including studies on non-small cell lung cancer (NSCLC) .
Field of Research
Cell Biology, Protein Biochemistry, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.