Products for Research Use Only
RegisterLogin

TM471-1

CAT: 0013-GTR19263118-02Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19263118-02Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TM471-1 is an orally active, covalent Bruton’s tyrosine kinase (BTK) inhibitor displaying an IC0 value of 1.3 nM for BTKWT, > 40000 nM for BTKC481S, 7.9 nM for TEC, and 12.4 nM for TXK. It inhibits cell growth both in vitro and in vivo, arrests the cell cycle at the G0/G1 phase, and induces apoptosis.
CAS Number
2649008-95-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
C (N) (=O) C=1N2C ([C@@H] (CCN2) C3CCN (C (C=C) =O) CC3) =NC1C4=CC=C (OC5=CC=CC=C5) C=C4
Molecular Formula
C27H29N5O3
Molecular Weight
471.55
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ryq3xey2TM
CAS Number2649008-95-5
PubChem CID175683814
IUPAC Name(8S)-2-(4-phenoxyphenyl)-8-(1-prop-2-enoylpiperidin-4-yl)-5,6,7,8-tetrahydroimidazo[1,2-b]pyridazine-3-carboxamide
Molecular FormulaC27H29N5O3
Molecular Weight471.5
XLogP3.9
Topological Polar Surface Area102
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count35
Formal Charge0
Complexity756
SMILES
C=CC(=O)N1CCC(CC1)[C@@H]2CCNN3C2=NC(=C3C(=O)N)C4=CC=C(C=C4)OC5=CC=CC=C5
InChI
InChI=1S/C27H29N5O3/c1-2-23(33)31-16-13-18(14-17-31)22-12-15-29-32-25(26(28)34)24(30-27(22)32)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,18,22,29H,1,12-17H2,(H2,28,34)/t22-/m0/s1
InChIKey
BTTAGXOSKCWYGQ-QFIPXVFZSA-N
Chemical Structure
2D Structure
2D structure of Ryq3xey2TM
CAS: 2649008-95-5
CID: 175683814
Formula: C27H29N5O3
MW: 471.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.5
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass471.22703980
Monoisotopic Mass471.22703980
Topological Polar Surface Area102 Ų
Heavy Atom Count35
Formal Charge0
Complexity756
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19169514-011,1,1,1-Kestohexaose
GTR19217879-01AMPK-α1β1γ1 activator 1
GTR191890321,1,1-Tribromoacetone
GTR191901241-Bromo-1,1-dichloroacetone
GTR19218855-01TWIK-1/TREK-1-IN-1
GTR191902241,1,1,3-Tetrachloroacetone
GTR19221683-011,1′,1′′,1′′′-[1,4-Piperazinediylbis (2,1-ethanediylnitrilo) ]tetrakis[2-dodecanol]
GTR19264158-01C22:1 1-Deoxyceramide (m18:1/22:1)
GTR19276756-013-Aminobicyclo[1.1.1]pentane-1-carbonitrile
GTR180271691.1 Antibody

Alternative Products

CatalogName
T210604-01TM471-1
OF59775-011,1,1,1,1-Kestoheptaose
N2864-5.11,1,1,1-Kestohexaose
1120401,1,1,1-Kestohexose
410417-011,1,1-Trichloromethanesulfonic Acid 1,1'-Anhydride
IFA69273-011-Iodobicyclo[1.1.1]pentane
OR3123881-Phenylbicyclo[1.1.1]pentane
HY-157129AMPK-α1β1γ1 activator 1
OR3001791-Isothiocyanatobicyclo[1.1.1]pentane

Popular Products