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TM471-1

CAT: 0013-GTR19263118-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263118-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TM471-1 is an orally active, covalent Bruton’s tyrosine kinase (BTK) inhibitor displaying an IC0 value of 1.3 nM for BTKWT, > 40000 nM for BTKC481S, 7.9 nM for TEC, and 12.4 nM for TXK. It inhibits cell growth both in vitro and in vivo, arrests the cell cycle at the G0/G1 phase, and induces apoptosis.
CAS Number
2649008-95-5
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
C (N) (=O) C=1N2C ([C@@H] (CCN2) C3CCN (C (C=C) =O) CC3) =NC1C4=CC=C (OC5=CC=CC=C5) C=C4
Molecular Formula
C27H29N5O3
Molecular Weight
471.55
Storage Conditions
-20°C
Notes
For research use only.

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