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AKT-IN-28

CAT: 0013-GTR19263095-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263095-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AKT-IN-28 is an allosteric inhibitor of Akt and a derivative of Shikonin. It effectively binds to Akt's allosteric site through hydrophobic and hydrogen bond interactions, with a Kd value of 2.07 μM. AKT-IN-28 significantly inhibits Akt activity, inducing apoptosis in KRAS-mutant colorectal cancer cells, arresting the cell cycle at the G2/M phase, and suppressing cell proliferation, migration, and metabolism.
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Protein Biochemistry, Signal Transduction, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.

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