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Trivalent GalNAc-DBCO

CAT: 0013-GTR19263060-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19263060-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Trivalent GalNAc-DBCO is a synthetic ligand composed of three GalNAc units linked to DBCO. Trivalent GalNAc-DBCO undergoes strain-promoted alkyne–azide cycloaddition (SPAAC) reactions with azide-containing molecules without the need for copper catalysis. Trivalent GalNAc-DBCO binds specifically to the asialoglycoprotein receptor (ASGPR), thereby directing conjugated molecules into hepatocytes for lysosomal degradation through receptor-mediated endocytosis. Trivalent GalNAc-DBCO is extensively applied in studies of liver-targeted drug delivery, targeted degradation strategies, and hepatocyte-specific molecular engineering.
CAS Number
2765060-22-6
Field of Research
Neuroscience
Purity
96.33% (May vary between batches)
Smiles
C (CCC (NCCOCCOCCOCCOCCC (NC (COCCC (NCCCNC (CCCCO[C@H]1[C@H] (NC (C) =O) [C@@H] (O) [C@@H] (O) [C@@H] (CO) O1) =O) =O) (COCCC (NCCCNC (CCCCO[C@H]2[C@H] (NC (C) =O) [C@@H] (O) [C@@H] (O) [C@@H] (CO) O2) =O) =O) COCCC (NCCCNC (CCCCO[C@H]3[C@H] (NC (C) =O) [C@@H] (O) [C@@H] (O) [C@@H] (CO) O3) =O) =O) =O) =O) (=O) N4C=5C (C#CC=6C (C4) =CC=CC6) =CC=CC5
Molecular Formula
C91H144N12O34
Molecular Weight
1950.18
Storage Conditions
-20°C
Notes
For research use only.

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