Goat Human Factor XI Antibody

CAT: 0013-GTR17700588Size: 1 mLDry Ice: NoHazardous: No

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CAT#:0013-GTR17700588Size:1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Goat polyclonal antibody to Factor XI.

UniProt

P03951

Reactivity

Human

Clonality

Polyclonal

Conjugation

Unconjugated

Source

Factor XI is a glycoprotein (MW 160,000) composed of two identical polypeptide chains. In electrophoresis it migrates in the gamma region. It is stable on storage, heat \stable at 56oC for 30 minutes and not adsorbed by gels. Factor XI also occurs in platelets (MW 52,000) . Factor XI is converted to an active enzyme by FXIIa but can be activated by other proteases such as trypsin. FXIa activates FIX, but can also activate FXII and plasminogen. Platelet membrane FXI can substitute for plasma FXI in coagulation. Plasma FXI is used for immunization. Freund’s complete adjuvant is used in the first step of the immunization procedure.

Field of Research

Cell Biology

Form

Delipidated, heat inactivated, lyophilized, stable whole serum. No preservative added. Total protein and IgG concentrations in the antiserum are comparable to those of pooled normal goat serum. No foreign proteins added.

Storage Conditions

Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Notes

For research use only.

Host or Source

Goat

UniProtKB · P03951

Coagulation factor XI

FA11_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P03951
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: F11
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: FXI
EC number: 3.4.21.27
Processing: Precursor
Secondary accessions: D3DP64, Q4W5C2, Q9Y495

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

Disease

Disease variant

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

Heparin-bindingHydrolaseProteaseSerine protease

Domain

RepeatSignal

Cellular component

Secreted

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