Products for Research Use Only
RegisterLogin

ARCC-4

CAT: 0804-HY-130492-06Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-130492-06Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ARCC-4 is a low-nanomolar Androgen Receptor (AR) degrader based on PROTAC, with a DC50 of 5 nM. ARCC-4 is an enzalutamide-based von Hippel-Lindau (VHL) -recruiting AR PROTAC and outperforms enzalutamide. ARCC-4 effectively degrades clinically relevant AR mutants associated with antiandrogen therapy[1].
CAS Number
1973403-00-7
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Androgen Receptor; PROTACs
Type
Reference compound
Related Pathways
PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arcc-4.html
Purity
99.88
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)NC(COCCCCOC4=CC=C(C5=CC=C(N(C(N6C7=CC=C(C#N)C(C(F)(F)F)=C7)=S)C(C)(C)C6=O)C=C5)C=C4)=O)=O)C[C@H](O)C3
Molecular Formula
C53H56F3N7O7S2
Molecular Weight
1024.18
Precautions
H315, H319, H320
References & Citations
[1]Salami J, et al. Androgen receptor degradation by the proteolysis-targeting chimera ARCC-4 outperforms enzalutamide in cellular models of prostate cancer drug resistance. Commun Biol. 2018 Aug 2;1:100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Von Hippel-Lindau (VHL)

Chemical Information

(2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number1973403-00-7
PubChem CID122428515
IUPAC Name(2S,4R)-1-[(2S)-2-[[2-[4-[4-[4-[3-[4-cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-sulfanylideneimidazolidin-1-yl]phenyl]phenoxy]butoxy]acetyl]amino]-3,3-dimethylbutanoyl]-4-hydroxy-N-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl]pyrrolidine-2-carboxamide
Molecular FormulaC53H56F3N7O7S2
Molecular Weight1024.2
XLogP8.5
Topological Polar Surface Area238
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count14
Rotatable Bond Count18
Heavy Atom Count72
Formal Charge0
Complexity1940
SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCCCOC4=CC=C(C=C4)C5=CC=C(C=C5)N6C(=S)N(C(=O)C6(C)C)C7=CC(=C(C=C7)C#N)C(F)(F)F)O
InChI
InChI=1S/C53H56F3N7O7S2/c1-32-45(72-31-59-32)36-11-9-33(10-12-36)28-58-47(66)43-26-40(64)29-61(43)48(67)46(51(2,3)4)60-44(65)30-69-23-7-8-24-70-41-21-16-35(17-22-41)34-13-18-38(19-14-34)63-50(71)62(49(68)52(63,5)6)39-20-15-37(27-57)42(25-39)53(54,55)56/h9-22,25,31,40,43,46,64H,7-8,23-24,26,28-30H2,1-6H3,(H,58,66)(H,60,65)/t40-,43+,46-/m1/s1
InChIKey
DUPAJELXESPTNF-PPZGWQTASA-N
Chemical Structure
2D Structure
2D structure of (2S,4R)-1-((S)-2-(2-(4-((4'-(3-(4-Cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-[1,1'-biphenyl]-4-yl)oxy)butoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS: 1973403-00-7
CID: 122428515
Formula: C53H56F3N7O7S2
MW: 1024.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1024.2
XLogP38.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count14
Rotatable Bond Count18
Exact Mass1023.36347398
Monoisotopic Mass1023.36347398
Topological Polar Surface Area238 Ų
Heavy Atom Count72
Formal Charge0
Complexity1940
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-W099255-01Ethyl 4,4,4,4',4',4'-hexafluoro-DL-valinate
HY-W7200064,4'-Diapo-ω, ω-carotene-4,4'-dial
HY-77910-014- (4-Bromophenyl) -4-hydroxypiperidine
HY-W037331-014,4-Difluorobenzhydrol
HY-B1955-014',4-Dibromobiphenyl
HY-W002564-014,4-Dimethylcyclohexanone
HY-135324-014,4'-Iminodiphenol
HY-W017289-014,4′-Dipyridyl
HY-W016189-014,4'-Dihydroxybiphenyl
HY-W034556-014,4'-Trimethylenedipyridine

Alternative Products

CatalogName
T14318-01ARCC-4
7254/5ARCC 4
A23907-100ARCC-4 100mg
A23907-50ARCC-4 50mg
A23907-10ARCC-4 10mg
A23907-5ARCC-4 5mg
MBS5801311ARCC 4 negative control
GTR17973391ArcC Antibody
MBS1424785-01Recombinant Oenococcus oeni Carbamate kinase (arcC)
MBS1203210-01Recombinant Bacillus licheniformis Carbamate kinase (arcC)

Popular Products