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MS8847

CAT: 0013-GTR19261771-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19261771-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS8847 is a potent EZH2PROTAC degrader that recruits the E3 ligase von Hippel-Lindau (VHL) . It degrades EZH2 efficiently through a ubiquitin-proteasome system-dependent mechanism. MS8847 effectively inhibits the growth of acute myeloid leukemia (AML) and triple-negative breast cancer (TNBC) cells.
CAS Number
3050872-59-5
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Smiles
N (CC) (C1=CC (=CC (C (NCC2=C (C) C=C (C) NC2=O) =O) =C1C) C3=CC=C (CN4CCN (CCC (NCCCCCCCCCCC (N[C@H] (C (=O) N5[C@H] (C (NCC6=CC=C (C=C6) C7=C (C) N=CS7) =O) C[C@@H] (O) C5) [C@] (C) (C) C) =O) =O) CC4) C=C3) C8CCOCC8
Molecular Formula
C70H98N10O8S
Molecular Weight
1239.65
Storage Conditions
-20°C
Notes
For research use only.

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