Ceramide 3

• Description:

  C18 Phytoceramide (t18:0/18:0) (Cer (t18:0/18:0) ) is a bioactive sphingolipid found in the stratum corneum of Saccharomyces cerevisiae, wheat grain, and mammalian epidermis. Cer (t18:0/18:0) consists of a phytosphingosine backbone amine linked to a C18 fatty acid chain. Cer (t18:0/18:0) has the function of regulating apoptosis, cell differentiation, proliferation of smooth muscle cells and inhibition of mitochondrial respiratory chain. It also suppresses the expression of allergic cytokines IL-4, TNF-α, and transcription factors c-Jun and NF-κB in histone-stimulated mouse skin tissue. Formulations containing cer (t18:0/18:0) have been used as skin protectants in cosmetics as they reduce water loss and prevent epidermal dehydration and irritation.

• Product Name Alternative:

  N-Stearoyl phytosphingosine

• UNSPSC:

  12352200

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Biochemical Assay Reagents

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ceramide-3.html

• Purity:

  98.0

• Solubility:

  Methanol : 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@H](CO)NC(CCCCCCCCCCCCCCCCC)=O

• Molecular Formula:

  C36H73NO4

• Molecular Weight:

  583.97

• Precautions:

  H302, H315, H319, H335

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [34354-88-6]