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GPS167

CAT: 0013-GTR19264785-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264785-01Size:1 mg
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Description
GPS167 is a specific small-molecule splicing regulator and SRSF10 inhibitor that modulates BCLAF1 alternative splicing with an IC50 of 2 μM in human colorectal HCT116 cells, while also directly inhibiting CLK1, CLK2, and CLK4 but not SRPK1 or DYRK1A, positioning it as a mechanistically well-defined probe for studying spliceosome regulation and kinase-dependent RNA processing.
CAS Number
3034312-19-8
Purity
99.13% (May vary between batches)
Smiles
O=C (NC=1C=CC=2NN=CC2C1) C=3N=C (SC3) NC=4C=CC=CC4
Molecular Formula
C17H13N5OS
Molecular Weight
335.38
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-anilino-N-(1H-indazol-5-yl)-1,3-thiazole-4-carboxamide
CAS Number3034312-19-8
PubChem CID155927403
IUPAC Name2-anilino-N-(1H-indazol-5-yl)-1,3-thiazole-4-carboxamide
Molecular FormulaC17H13N5OS
Molecular Weight335.4
XLogP3.6
Topological Polar Surface Area111
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count24
Formal Charge0
Complexity445
SMILES
C1=CC=C(C=C1)NC2=NC(=CS2)C(=O)NC3=CC4=C(C=C3)NN=C4
InChI
InChI=1S/C17H13N5OS/c23-16(19-13-6-7-14-11(8-13)9-18-22-14)15-10-24-17(21-15)20-12-4-2-1-3-5-12/h1-10H,(H,18,22)(H,19,23)(H,20,21)
InChIKey
CYVGSDYVNUNREA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-anilino-N-(1H-indazol-5-yl)-1,3-thiazole-4-carboxamide
CAS: 3034312-19-8
CID: 155927403
Formula: C17H13N5OS
MW: 335.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight335.4
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass335.08408123
Monoisotopic Mass335.08408123
Topological Polar Surface Area111 Ų
Heavy Atom Count24
Formal Charge0
Complexity445
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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