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TH301

CAT: 0013-GTR19264775-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264775-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TH301 acts as a stabilizer for cryptochrome circadian regulator 2 (CRY2) . It demonstrates selectivity by stabilizing CRY2 over CRY1 in a degradation assay conducted with HEK293 cells expressing CRY reporters at concentrations ranging from 0.1 to 10 μM. In wild-type mouse fibroblasts, TH301 extends the circadian period, but this effect is absent in Cry2-/- fibroblasts. Additionally, it boosts rosiglitazone-dependent induction of brown adipose tissue-specific genes such as Ucp1, Cidea, and Kcnk3 in primary mouse stromal vascular fractions.
Storage Conditions
-20°C
Notes
For research use only.

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TBI3909-25MGTH301, CRY2 stabilizer (selective)

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