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TNI-97

CAT: 0013-GTR19264105-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19264105-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TNI-97 is a selective, orally active HDAC6 inhibitor with an IC50 value of 0.2 nM. It significantly suppresses the growth and colony-forming abilities of the triple-negative breast cancer (TNBC) cell line MDA-MB-453. In these cells, TNI-97 induces widespread cell death, including apoptosis, necroptosis, and pyroptosis. Additionally, TNI-97 demonstrates antitumor activity in mouse models bearing MDA-MB-453 xenograft tumors or syngeneic mouse-derived TNBC cell allograft tumors. TNI-97 is useful for researching triple-negative breast cancer.
CAS Number
2790425-52-2
Field of Research
Cell Biology, Epigenetics & Chromatin, Immunology & Inflammation, Molecular Biology, Musculoskeletal & Connective Tissue Research
Smiles
O=C (NO) C1=CC=C (C=C1) CN2N=C (C=C2C (F) (F) F) C3=CC=C4C (N=NN4C) =C3
Molecular Formula
C19H15F3N6O2
Molecular Weight
416.36
Storage Conditions
-20°C
Notes
For research use only.

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