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ZSH-2208

CAT: 0013-GTR19259508-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259508-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZSH-2208 is a synthetic analog of all-trans retinoic acid (ATRA) designed to overcome resistance and improve differentiation therapy in acute promyelocytic leukemia (APL) and other malignancies. In published studies, ZSH-2208 has shown superior anti-proliferative and pro-differentiation activity compared to ATRA in ATRA-resistant APL cell lines such as NB4-R2. For example, ZSH-2208 induced significant G1 phase arrest and granulocytic differentiation in NB4-R2 cells at concentrations around 1–10 μM, whereas ATRA was largely ineffective at equivalent doses. In mouse xenograft models, ZSH-2208 treatment led to marked tumor growth inhibition without the rapid metabolic degradation seen with ATRA. These data suggest that ZSH-2208 is a promising candidate for treating retinoic acid-resistant leukemias and potentially other cancers sensitive to retinoid signaling.
CAS Number
2131803-75-1
Purity
0.98
Molecular Formula
C20H18O3S
Molecular Weight
338.0977
Notes
For research use only.

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