Products for Research Use Only
RegisterLogin

AZD1979

CAT: 0013-GTR19258949-05Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19258949-05Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZD1979 is a potent and selective MCHR1 antagonist (IC50 = 12 nM) with demonstrated CNS exposure. It has been utilized in obesity research, showing enhanced insulin sensitivity in preclinical models, making it a valuable tool for in vitro and in vivo metabolic studies.
CAS Number
1254035-84-1
Product Name Alternative
AZD1979, AZD-1979, AZD 1979, MCHr1
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
99.72% (May vary between batches)
Solubility
DMSO:30 mg/mL (64.86 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.32 mM)
Smiles
O=C (C1=NN=C (O1) C=2C=CC (OC) =CC2) N3CC (OC4=CC=C (C=C4) CN5CC6 (COC6) C5) C3
Molecular Formula
C25H26N4O5
Molecular Weight
462.5
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl)(3-(4-(2-oxa-6-azaspiro(3.3)hept-6-ylmethyl)phenoxy)-1-azetidinyl)methanone

AZD1979 is a carboxamide resulting from the formal condensation of the carboxy group of 5-(p-methoxyphenyl)-1,3,4-oxadiazole-2-carboxylic acid with the amino group of 3-phenoxyazetidine and in which the phenoxy group has been substituted at the para- position by a 2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl group. It is a melanin concentrating hormone receptor 1 (MCHr1) antagonist. It has a role as a melanin-concentrating hormone receptor antagonist. It is an aromatic ether, an azaspiro compound, a carboxamide, an oxaspiro compound, a member of oxetanes, an oxadiazole and a N-acylazetidine. It is a conjugate base of an AZD1979(1+).

CAS Number1254035-84-1
PubChem CID49801838
IUPAC Name[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy]azetidin-1-yl]methanone
Molecular FormulaC25H26N4O5
Molecular Weight462.5
XLogP2
Topological Polar Surface Area90.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity706
SMILES
COC1=CC=C(C=C1)C2=NN=C(O2)C(=O)N3CC(C3)OC4=CC=C(C=C4)CN5CC6(C5)COC6
InChI
InChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3
InChIKey
BKKPIQPFRAPEAY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of (5-(4-Methoxyphenyl)-1,3,4-oxadiazol-2-yl)(3-(4-(2-oxa-6-azaspiro(3.3)hept-6-ylmethyl)phenoxy)-1-azetidinyl)methanone
CAS: 1254035-84-1
CID: 49801838
Formula: C25H26N4O5
MW: 462.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight462.5
XLogP32
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass462.19031994
Monoisotopic Mass462.19031994
Topological Polar Surface Area90.2 Ų
Heavy Atom Count34
Formal Charge0
Complexity706
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19166921-01AZD9977
GTR19171882-01AZD1981
GTR19195498-01AZD1940
GTR19160242-01AZD1981

Alternative Products

CatalogName
BA5538-5.1AZD1979

Popular Products