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YAP-IN-1

CAT: 0013-GTR19258664-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258664-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YAP-IN-1 (Compound (+) -1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.
Field of Research
Cancer Biology, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.

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HY-P2244-01YAP-TEAD-IN-1
405612-01YAP
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HY-168016-01PROTAC YAP degrader-1
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