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SKP-451

CAT: 0013-GTR19258588-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258588-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SKP-451 is an ATP-sensitive potassium (K+) channel agonist. It activates ATP-sensitive K+ channels, promoting the efflux of K+, leading to membrane hyperpolarization and inhibiting Ca2+ influx, which results in the relaxation of vascular smooth muscle. SKP-451 relaxes canine coronary arteries, rabbit basilar arteries, and vertebral arteries. Additionally, SKP-451 lowers mean arterial blood pressure in conscious spontaneously hypertensive rats (SHR) . It holds potential for cardiovascular disease research.
CAS Number
181137-41-7
Field of Research
Pharmacology & Drug Discovery
Smiles
N (=O) (=O) C=1C=C2C (=C[C@] (C) (OC2=CC1) [C@@H]3OCCO3) N4C (=O) CCC4
Molecular Formula
C17H18N2O6
Molecular Weight
346.335
Storage Conditions
-20°C
Notes
For research use only.

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