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AMG28

CAT: 0013-GTR19258574-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258574-01Size:10 mg
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Description
AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.
CAS Number
1202764-07-5
Field of Research
Signal Transduction
Smiles
OC (C#CC=1C=CC=2NC3=C (C=4N=C (N=CC4CCC3) N) C2C1) (C) C
Molecular Formula
C20H20N4O
Molecular Weight
332.399
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-(2-Amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol
CAS Number1202764-07-5
PubChem CID58221549
IUPAC Name4-(4-amino-3,5,12-triazatetracyclo[9.7.0.02,7.013,18]octadeca-1(11),2,4,6,13(18),14,16-heptaen-16-yl)-2-methylbut-3-yn-2-ol
Molecular FormulaC20H20N4O
Molecular Weight332.4
XLogP2.4
Topological Polar Surface Area87.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity565
SMILES
CC(C)(C#CC1=CC2=C(C=C1)NC3=C2C4=NC(=NC=C4CCC3)N)O
InChI
InChI=1S/C20H20N4O/c1-20(2,25)9-8-12-6-7-15-14(10-12)17-16(23-15)5-3-4-13-11-22-19(21)24-18(13)17/h6-7,10-11,23,25H,3-5H2,1-2H3,(H2,21,22,24)
InChIKey
DGLFSNZWRYADFC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(2-Amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol
CAS: 1202764-07-5
CID: 58221549
Formula: C20H20N4O
MW: 332.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight332.4
XLogP32.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass332.16371127
Monoisotopic Mass332.16371127
Topological Polar Surface Area87.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity565
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-172545AMG28

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