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AMG28

CAT: 0804-HY-172545Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172545Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG28 is a Tau tubulin kinase 1 (TTBK1) and TTBK2 inhibitor with IC50s of 805 nM and 988 nM, respectively. AMG28 inhibits tau phosphorylation at Ser422 (IC50 of 1.85 μM) [1].
CAS Number
1202764-07-5
UNSPSC
12352005
Target
Tau Protein
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC(C)(O)C#CC1=CC2=C(NC3=C2C4=C(C=NC(N)=N4)CCC3)C=C1
Molecular Formula
C20H20N4O
Molecular Weight
332.40
References & Citations
[1]Bashore FM, et al. Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis. Sci Rep. 2023 Apr 14;13 (1) :6118.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19258574-01AMG28

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