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Z-3578

CAT: 0013-GTR19259423-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19259423-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Z-3578 is a small molecule antagonist targeting the MrgX2 (Mas-related G protein-coupled receptor X2) with notable anti-pseudoallergic properties, exhibiting a KD value of 729 nM. It effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, with IC50 values of 4.90 μM and 6.18 μM, respectively, suppresses the release of β-hexosaminidase, and significantly reduces the release of histamine and TNF-α, as well as intracellular calcium flux. Additionally, in a mouse pseudoallergy model, Z-3578 significantly alleviates foot swelling, dye leakage, and reduces serum histamine levels, indicating a strong in vivo anti-allergic effect. Z-3578 presents as a promising lead compound in the field of anti-allergic treatments, particularly for pseudoallergic reactions.
CAS Number
473687-20-6
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
O=C (NC1=CC=C (Cl) C=C1Cl) CSC=2N=NC (C3=CC=CC=C3) =C (N2) C=4C=CC=CC4
Molecular Formula
C23H16Cl2N4OS
Molecular Weight
467.37
Storage Conditions
-20°C
Notes
For research use only.

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