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TKB272

CAT: 0013-GTR19258513-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258513-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TKB272 is an orally active antiviral agent that selectively targets the main protease (Mpro) of SARS-CoV-2, effectively inhibiting the infection and replication of various strains, including Omicron variants (such as XBB.1.5 and EG.5.1) . It exhibits an enzyme inhibitory activity with an IC50 of 0.7 μM against SARS-CoV-2WK-521 Mpro and shows potent antiviral activity at the cellular level with an EC50 as low as 2.6 nM in HeLahACE2-TMPRSS2 cells against the BQ.1.1 strain. TKB272 also has a CC50 of 98 μM, indicating low cytotoxicity. Furthermore, it demonstrates a significant suppression of SARS-CoV-2XBB.1.5 replication in the B6.Cg-Tg (K18-hACE2) 2-Prlmn/J transgenic mouse model, suggesting potential use in the research of SARS-CoV-2 infections.
CAS Number
2892688-18-3
Field of Research
Infectious Disease & Virology
Smiles
C (N[C@H] (C (=O) C1=NC=2C (S1) =CC=C (F) C2) C[C@@H]3CCNC3=O) (=O) [C@@H]4[C@@]5 ([C@@] (C5 (C) C) (CN4C ([C@@H] (NC (C (F) (F) F) =O) [C@@] (C) (C) C) =O) [H]) [H]
Molecular Formula
C30H35F4N5O5S
Molecular Weight
653.688
Storage Conditions
-20°C
Notes
For research use only.

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