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R1-ICR-5

CAT: 0013-GTR19258415-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258415-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R1-ICR-5 is a selective PROTAC degrader targeting serine/threonine-protein kinase 1 (RIPK1) . Mediated by VHL, R1-ICR-5 promotes the degradation of RIPK1, disrupting the TNFR1 and TLR3/4 signaling hubs, enhancing NF-κB, MAPK, and IFN signal output, and facilitating RIPK3 activation and necroptosis induction. R1-ICR-5 holds potential for research in cancer and inflammatory diseases.
CAS Number
3070346-91-4
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
N (C (CCCCCCCCCCC (N[C@H] (C (=O) N1[C@H] (C (NCC2=CC=C (C=C2) C3=C (C) N=CS3) =O) C[C@@H] (O) C1) [C@] (C) (C) C) =O) =O) C=4SC=5C (N4) =CC=C (C5) C=6C=C (NC (OC7CCCCC7) =O) C (C) =NC6
Molecular Formula
C54H70N8O7S2
Molecular Weight
1007.31
Storage Conditions
-20°C
Notes
For research use only.

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