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Ran-IN-1

CAT: 0013-GTR19258410-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258410-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ran-IN-1 (Compound M36) is an orally active and selective inhibitor of Ran GTPase. It binds allosterically with high specificity to the switch II pocket of GDP-bound Ran (RanGDP), stabilizing its inactive state and reducing the formation of active Ran-GTP. Ran-IN-1 induces apoptosis in epithelial ovarian cancer (EOC) cells and inhibits DNA repair pathways such as homologous recombination (HR) and non-homologous end joining (NHEJ) . This compound shows potential for research in epithelial ovarian cancer, particularly in high-grade serous carcinoma.
CAS Number
2301869-11-2
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Smiles
O (CC1=CC=C (F) C=C1) [C@H]2[C@@H] (OCC3=CC=C (F) C=C3) [C@H] (C (N) =S) O[C@@H]2COCC4=CC=C (F) C=C4
Molecular Formula
C27H26F3NO4S
Molecular Weight
517.56
Storage Conditions
-20°C
Notes
For research use only.

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