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VEGFR-2-IN-67

CAT: 0013-GTR19258393-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258393-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VEGFR-2-IN-67 (Compound 6b) functions as an inhibitor of vascular endothelial growth factor receptor 2 (VEGFR-2), with IC50 values of 5.91 μM for MDA-231 cells and 7.16 μM for MCF-7 cells. Its inhibitory activity on VEGFR-2 is comparable to Sorafenib (IC50 of 53.63 nM) . VEGFR-2-IN-67 exhibits significant anticancer activity by inducing cell apoptosis (with an early apoptosis rate of 57.20%), causing G1 phase cell cycle arrest, upregulating pro-apoptotic markers, and downregulating Bcl-2. This compound is utilized in cancer research.
Field of Research
Cardiovascular Research, Cardiovascular Research; Cell Biology, Signal Transduction
Storage Conditions
-20°C
Notes
For research use only.

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