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ASTX295

CAT: 0013-GTR19258389-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258389-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ASTX295 is a selective mouse double minute 2 (MDM2) antagonist with an IC50 value of less than 1 nM. It specifically inhibits the interaction between MDM2 and p53, reactivating wild-type (WT) TP53, which subsequently induces the expression of related transcriptional targets, leading to cell death and cell cycle arrest. ASTX295 holds potential for research in lymphoid malignancies such as diffuse large B-cell lymphoma (DLBCL), mantle cell lymphoma (MCL), and T-cell lymphoma.
CAS Number
2093449-12-6
Field of Research
Cell Biology
Smiles
O (C) [C@]1 (N ([C@@H] ([C@@H] (C (O) =O) C) C2=CC=C (Cl) C=C2) C (=O) C=3C1=C (F) C=C ([C@@] (CC) (O) C4CCOCC4) C3) C5=CC=C (Cl) C=C5
Molecular Formula
C33H34Cl2FNO6
Molecular Weight
630.531
Storage Conditions
-20°C
Notes
For research use only.

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