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NLRP3-IN-78

CAT: 0013-GTR19258343-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258343-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLRP3-IN-78 (compound 21) is an NLRP3 inhibitor with a 46.72% inhibition rate of GSDMD-induced pyroptosis at 5 μM. It binds to the NLRP3 protein and prevents GSDMD-NT oligomerization. Additionally, NLRP3-IN-78 inhibits GSDMD cleavage and upstream NF-κB signaling, demonstrating anti-inflammatory activity.
CAS Number
477546-27-3
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Smiles
O=C (NC1=NC (=CS1) C=2C=C (Cl) SC2Cl) C=3OC (=CC3) N (=O) =O
Molecular Formula
C12H5Cl2N3O4S2
Molecular Weight
390.222
Storage Conditions
-20°C
Notes
For research use only.

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