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TCL1

CAT: 0013-GTR19258187-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258187-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
CAS Number
875165-39-2
Field of Research
Cell Biology, Protein Biochemistry
Smiles
O=C (O) CC1SC2=NN=C (N2N=C1C=3C=CC (Cl) =CC3) CC4=CC=C (Br) C=C4
Molecular Formula
C19H14BrClN4O2S
Molecular Weight
477.762
Storage Conditions
-20°C
Notes
For research use only.

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