Products for Research Use Only
RegisterLogin

TCL1

CAT: 0013-GTR19258187-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19258187-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.
CAS Number
875165-39-2
Field of Research
Cell Biology, Protein Biochemistry
Smiles
O=C (O) CC1SC2=NN=C (N2N=C1C=3C=CC (Cl) =CC3) CC4=CC=C (Br) C=C4
Molecular Formula
C19H14BrClN4O2S
Molecular Weight
477.762
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-{3-[(4-bromophenyl)methyl]-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl}acetic acid
CAS Number875165-39-2
PubChem CID16275235
IUPAC Name2-[3-[(4-bromophenyl)methyl]-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl]acetic acid
Molecular FormulaC19H14BrClN4O2S
Molecular Weight477.8
XLogP4.7
Topological Polar Surface Area106
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity596
SMILES
C1=CC(=CC=C1CC2=NN=C3N2N=C(C(S3)CC(=O)O)C4=CC=C(C=C4)Cl)Br
InChI
InChI=1S/C19H14BrClN4O2S/c20-13-5-1-11(2-6-13)9-16-22-23-19-25(16)24-18(15(28-19)10-17(26)27)12-3-7-14(21)8-4-12/h1-8,15H,9-10H2,(H,26,27)
InChIKey
BWGPJTANFXCCTH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-{3-[(4-bromophenyl)methyl]-6-(4-chlorophenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-7-yl}acetic acid
CAS: 875165-39-2
CID: 16275235
Formula: C19H14BrClN4O2S
MW: 477.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight477.8
XLogP34.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count5
Exact Mass475.97094
Monoisotopic Mass475.97094
Topological Polar Surface Area106 Ų
Heavy Atom Count28
Formal Charge0
Complexity596
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR18124021TCL1A Antibody
GTR18136735TCL1A Antibody
GTR18193823-01TCL1A Antibody
GTR18914107TCL1A Peptide
GTR18712749-01TCL1A Antibody
GTR18591693-01TCL1B Antibody
GTR18613124TCL1B Antibody
GTR18056344-01TCL1A Antibody
GTR18593697-01TCL1A Antibody
GTR17905672-01TCL1A Antibody

Alternative Products

CatalogName
CR401-0.5mlTCL1
MBS8541348-01TCL1 (ABT-TCL1) Mouse mAb
MBS9510733-01Anti-TCL1 Antibody [ABT-TCL1]
10R-6614TCL1 antibody
LR-1014pLuc3U-TCL1
542980-01Tcl1 discontinued

Popular Products