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ALK-IN-31

CAT: 0013-GTR19257985-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257985-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALK-IN-31 (Compound Ld-10) is an orally active ALK inhibitor with an IC50 of 1135 nM. It demonstrates excellent antiproliferative activity against lung cancer cells H2228, with an IC50 value of 1.35 μM. ALK-IN-31 induces apoptosis and arrests cell proliferation at the G0/G1 phase by affecting mitochondrial function. It exhibits antitumor effects by downregulating the expression of p-AKT and p-mTOR in the PI3K-AKT-mTOR signaling pathway downstream of ALK. This compound is applicable for research into non-small cell lung cancer (NSCLC) .
CAS Number
3043840-25-8
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C1C2=CC=C (C=C2CCC1) NC=3N=C (NC=4C=CC=CC4NC (=O) C5CCCCC5) C6=C (N3) CCSC6
Molecular Formula
C30H33N5O2S
Molecular Weight
527.68
Storage Conditions
-20°C
Notes
For research use only.

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