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STAT3-D11-PROTAC-VHL

CAT: 0013-GTR19257886-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257886-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT3-D11-PROTAC-VHL (Compound D11-PROTAC) is a PROTAC degrader targeting signal transducer and activator of transcription 3 (STAT3) . It demonstrates anti-tumor activity with IC50 values of 1335 nM in HeLa cells and 1973 nM in MCF-7 cells. The compound binds to the DNA binding domain of STAT3, recruits the E3 ligase VHL to form a ternary complex, leading to ubiquitination and subsequent proteasomal degradation of STAT3. Additionally, STAT3-D11-PROTAC-VHL inhibits tumor cell growth, induces cell cycle arrest and apoptosis (apoptosis), and suppresses tumor immune evasion.
Field of Research
Cancer Biology; Cell Biology, Cell Biology, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Storage Conditions
-20°C
Notes
For research use only.

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