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OPB-3206

CAT: 0013-GTR19257795-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257795-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OPB-3206 is a selective inhibitor of matrix metalloproteinases (MMPs) . It inhibits stromelysin, collagenase, gelatinase A (MMP-2), and gelatinase B (MMP-9) with IC50 values of 7x10^-7 M, 5x10^-6 M, 5x10^-7 M, and 2x10^-6 M, respectively. OPB-3206 reversibly binds to the zinc-binding site of MMPs, blocking the activation of MMP-9 and reducing the degradation of the extracellular matrix, thereby inhibiting tumor lung metastasis. OPB-3206 shows potential for research in osteosarcoma lung metastasis.
CAS Number
166245-54-1
Field of Research
Protein Biochemistry, Stem Cell & Developmental Biology
Smiles
O (C) N1C=2C (C[C@H] (NC ([C@@H] (CC (NO) =O) CC (C) C) =O) C1=O) =CC=CC2
Molecular Formula
C18H25N3O5
Molecular Weight
363.41
Storage Conditions
-20°C
Notes
For research use only.

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