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ABT-384

CAT: 0013-GTR19257541-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257541-02Size:5 mg
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Description
ABT-384 is a potent and selective 11β-HSD1 inhibitor, reducing enzyme activity in the liver and CNS. It modulates the HPA axis, increasing ACTH, cortisol, and sex hormones, supporting its investigation in preclinical models for Alzheimer's disease and major depressive disorder research.
CAS Number
868623-40-9
Product Name Alternative
ABT 384, ABT384, ABT-384
Field of Research
Metabolism Research
Purity
99.86% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.05 mM) ; DMSO:24 mg/mL (48.62 mM)
Smiles
CC (C) (N1CCN (CC1) c1ccc (cn1) C (F) (F) F) C (=O) NC1C2CC3CC1CC (C3) (C2) C (N) =O
Molecular Formula
C25H34F3N5O2
Molecular Weight
493.58
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide

ABT-384 has been used in trials studying the treatment of Alzheimer's Disease.

CAS Number868623-40-9
PubChem CID11670435
IUPAC Name4-[[2-methyl-2-[4-[5-(trifluoromethyl)-2-pyridinyl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide
Molecular FormulaC25H34F3N5O2
Molecular Weight493.6
XLogP2.6
Topological Polar Surface Area91.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity825
SMILES
CC(C)(C(=O)NC1C2CC3CC1CC(C3)(C2)C(=O)N)N4CCN(CC4)C5=NC=C(C=C5)C(F)(F)F
InChI
InChI=1S/C25H34F3N5O2/c1-23(2,33-7-5-32(6-8-33)19-4-3-18(14-30-19)25(26,27)28)22(35)31-20-16-9-15-10-17(20)13-24(11-15,12-16)21(29)34/h3-4,14-17,20H,5-13H2,1-2H3,(H2,29,34)(H,31,35)
InChIKey
CLHMYBJIOZXCEX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[[2-Methyl-2-[4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl]propanoyl]amino]adamantane-1-carboxamide
CAS: 868623-40-9
CID: 11670435
Formula: C25H34F3N5O2
MW: 493.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight493.6
XLogP32.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass493.26645983
Monoisotopic Mass493.26645983
Topological Polar Surface Area91.6 Ų
Heavy Atom Count35
Formal Charge0
Complexity825
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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