Products for Research Use Only
RegisterLogin

CARM1-IN-1

CAT: 0804-HY-12759-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-12759-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CARM1-IN-1 (compound 7g) is a highly potent and selective inhibitor of CARM1 (IC50=8.6 μM, CARM1/PABP1), with low inhibitory activity against PRMT1 and SET7 (IC50 >667 μM) . CARM1-IN-1 inhibits the methylation activity of CARM1 and the methylation levels of different substrates, such as PABP1, CA150, SmB, and H3. CARM1-IN-1 also inhibits the promoter activity of prostate-specific antigen (PSA) without significant cytotoxicity[1].
CAS Number
1020399-49-8
UNSPSC
12352005
Target
Histone Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/CARM1-IN-1.html
Purity
95.0
Solubility
DMSO : ≥ 35 mg/mL
Smiles
O=C1/C(CN(CC2=CC=CC=C2)C/C1=C\C3=CC=C(O)C(Br)=C3)=C/C4=CC=C(O)C(Br)=C4
Molecular Formula
C26H21Br2NO3
Molecular Weight
555.26
References & Citations
[1]Cheng D, et al. Novel 3,5-bis (bromohydroxybenzylidene) piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14;54 (13) :4928-32.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT4

Related Products

CatalogName
HY-157388-01CARM1/HDAC2-IN-1
HY-172369CARM1/IKZF3 ligand 1
HY-161334CARM1-IN-4
HY-163561-01CARM1-IN-6
HY-158158CARM1-IN-5
HY-15214-01CARM1-IN-3
HY-172368PROTAC CARM1/IKZF3 degrader-1
HY-163561ACARM1-IN-6 (dihydrochloride)
HY-P790095-01CARM1, Human (His)
HY-15214A-01CARM1-IN-3 (dihydrochloride)

Alternative Products

CatalogName
C04394CARM1-IN-1
T64186-01CARM1-IN-1 hydrochloride
GTR19230303-01CARM1 degrader-1
T209000-01CARM1/HDAC2-IN-1
477108CARM1
NBP3-20909CL1Mouse Monoclonal Carm1 Antibody (CARM1/7426) [CoraFluor 1]
GTR19249415-01CARM1/IKZF3 ligand 1
PPL01936-2aPcDNA3.1 (+) -Flag-CARM1
PPLAV03691-1PLenti-CARM1 shRNA-1
abx456506-01Histone-Arginine Methyltransferase CARM1 (CARM1) Antibody

Popular Products