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ML346

CAT: 0804-HY-18669-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-18669-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 μM for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1].
CAS Number
[100872-83-1]
UNSPSC
12352005
Hazard Statement
H315, H317, H318, H334, H335, H341, H361, H370, H413
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ML346.html
Concentration
10mM
Purity
98.25
Solubility
DMSO : 12.5 mg/mL (ultrasonic)
Smiles
O=C1NC(/C(C(N1)=O)=C/C=C/C2=CC=C(OC)C=C2)=O
Molecular Formula
C14H12N2O4
Molecular Weight
272.26
Precautions
H315, H317, H318, H334, H335, H341, H361, H370, H413
References & Citations
[1]Calamini B, et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases.Probe Reports from the NIH Molecular Libraries Program. Bethesda (MD) : National Center for Biotechnology Information (US) ; 2010-. 2012 Dec 17.|[2]Calamini B, et al. Small-molecule proteostasis regulators for protein conformational diseases. Nat Chem Biol. 2011 Dec 25;8 (2) :185-96.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

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530368ML346
A22182-1ML346 1mg
A22182-5ML346 5mg
A22182-10ML346 10mg
A22182-500ML346 500mg
A22182-2ML346 2mg
A22182-25ML346 25mg
A22182-50ML346 50mg
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