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Lipid PPz-2R1

CAT: 0013-GTR19256444-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19256444-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lipid PPz-2R1 is an ionizable cationic lipid employed in crafting lipid nanoparticles (LNPs) for mRNA delivery both in vitro and in vivo. LNPs with lipid PPz-2R1, encapsulating an mRNA reporter, target the lungs preferentially over the heart, liver, spleen, and kidneys in mice. Additionally, these LNPs, when encapsulating mRNA encoding phosphatase and tensin homolog (PTEN), enhance PTEN protein levels in PTEN-deficient Lewis lung carcinoma (LLC) cells. In an orthotopic murine LLC model, these Lipid PPz-2R1-containing LNPs, carrying PTEN mRNA, reduce tumor growth either when administered alone or alongside an antibody against programmed cell death protein 1 (PD-1) .
CAS Number
2832061-40-0
Field of Research
Metabolism Research
Smiles
O=C (OCCCCCCN1CCN (CC1) CCCCCCOC (=O) C (CCCCCC) CCCCCCCC) C (CCCCCC) CCCCCCCC
Molecular Formula
C48H94N2O4
Molecular Weight
763.27
Storage Conditions
-20°C
Notes
For research use only.

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